منابع مشابه
Dihydroartemisinin increases radiosensitivity of A549 lung cancer cells
Background: Radiotherapy is the gold standard in the treatment of lung cancer. However, the radiosensitization of cancerous cells requires further improvement. Here, we investigated the effect of dihydroartemisinin (DHA) on the radiosensitization of non-small cell lung cancer (NSCLC) cells. Methods: Cell proliferation and cell cycle assays were carried out using A549 cells exposed to DHA. The e...
متن کاملRadiosensitivity of Cells
Atomic radiations are a very diverse group of physical agents all of which, however, produce damage in living cells. The common property which links them is the ability to knock out electrons from the atoms and molecules through which they pass. This process, known as ionization, is the starting point of radiation injury. Mammalian cells are amongst the most sensitive of all living matter, and ...
متن کاملInhibition of mammalian target of rapamycin by rapamycin increases the radiosensitivity of esophageal carcinoma Eca109 cells
The aim of the present study was to investigate whether radiation induces the mammalian target of rapamycin (Rap) (mTOR) signaling pathway in esophageal carcinoma Eca109 cells, and whether mTOR inhibition by rapamycin increases Eca109 cell radiosensitivity. Changes in the levels of mTOR signaling pathway and DNA damage-repair proteins in Eca109 cells prior to and following radiation were determ...
متن کاملTargeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells
The mammalian target of rapamycin (mTOR) is a protein kinase that regulates protein translation, cell growth, and apoptosis. Rapamycin (RPM), a specific inhibitor of mTOR, exhibits potent and broad in vitro and in vivo antitumor activity against leukemia, breast cancer, and melanoma. Recent studies showing that RPM sensitizes cancers to chemotherapy and radiation therapy have attracted consider...
متن کاملEffect of uncouplers on radiosensitivity and mutagenicity in x-irradiated mammalian cells.
The number of x-irradiated mammalian cells surviving is markedly increased when the cells are incubated with an uncoupler of oxidative phosphorylation prior to or immediately after irradiation. This increase is greater in plateau-phase cells than in exponentially growing cells. The increase in survival is related to the potency of the uncouplers, which do not modify the effective x-ray dose. Th...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1970
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(70)86319-6